N-acetyl Glucosamine (NAG) is a skin-replenishing ingredient that helps to reduce signs of aging. It is a monosaccharide derivative of glucose, yes sugar. This substance is the major component of the extracellular matrix and is extensively distributed in connective, epithelial, and neural tissues. It is responsible for maintaining the skin’s moisture levels and helps to improve the appearance of the skin, giving it a dewy, hydrated look. Its benefits include; hydration, and may indirectly help to protect collagen synthesis, exfoliation, healing and reduce the appearance of facial hyperpigmentation.
NAG has been shown to reduce hyperpigmentation and can be combined with niacinamide to further increase its ability to reduce hyperpigmentation. One study showed that a formulation of 4% niacinamide and 2% NAG significantly reduced the appearance and amount of hyperpigmentation of age spots and uneven skin pigmentation. Other studies showed a reduction in facial hyperpigmentation using NAG alone. It inhibits the glycosylation of pro-tyrosinase, which results in the reduction of melanin in the skin. A similar study using niacinamide and NAG on women aged 35 to 60 showed an increase in the production of hyaluronic acid, resulting in improved hydration. Result -fine line reduction increased skin elasticity.
